[HTML][HTML] A Scoping Review of Primary Breast Cancer Risk Reduction Strategies in East and Southeast Asia

F Alpeza, CKY Loo, Q Zhuang, M Hartman, SSN Goh… - Cancers, 2025 - mdpi.com
Breast cancer (BC) screening enables early detection and timely treatment of cancer.
Improving the effectiveness of BC screening can be accomplished by personalizing …

The convergence of genomic medicine and translational omics in transforming breast cancer patient care

S Wu, Y Zheng, OI Olopade - The Journal of Clinical Investigation, 2024 - jci.org
Breast cancer is the most diagnosed cancer among women worldwide, with an estimated
2.3 million new cases and 670,000 deaths reported in 2022 (1). Advances in genomic …

Polygenic risk scores stratify breast cancer risk among women with benign breast disease

ME Sherman, SJ Winham, RA Vierkant… - JNCI: Journal of the …, 2024 - academic.oup.com
Background Most breast biopsies are diagnosed as benign breast disease, with 1.5-to 4-fold
increased breast cancer risk. Apart from pathologic diagnoses of atypical hyperplasia, few …

Population‐specific validation and comparison of the performance of 77‐and 313‐variant polygenic risk scores for breast cancer risk prediction

M Hovhannisyan, P Zemankova, P Nehasil… - Cancer, 2024 - Wiley Online Library
Background The polygenic risk score (PRS) allows the quantification of the polygenic effect
of many low‐penetrance alleles on the risk of breast cancer (BC). This study aimed to …

Utilizing polygenic risk score for breast cancer risk prediction in a Taiwanese population

YH Lin, CC Hung, GC Lin, IC Tsai, CY Lum… - Cancer Epidemiology, 2025 - Elsevier
Background Breast cancer has been the most frequently diagnosed cancer among women
in Taiwan since 2003. While genetic variants play a significant role in the elevated risk of …

[HTML][HTML] Polygenic Risk Score (PRS) Combined with NGS Panel Testing Increases Accuracy in Hereditary Breast Cancer Risk Estimation

N Tsoulos, E Papadopoulou, K Agiannitopoulos… - Diagnostics, 2024 - mdpi.com
Breast cancer (BC) is the most prominent tumor type among women, accounting for 32% of
newly diagnosed cancer cases. BC risk factors include inherited germline pathogenic gene …

An implementation study of the service model for genetic risk-based stratified breast cancer screening-Estonian results of the BRIGHT project

M Tamm, P Padrik, K Ojamaa, A Paas, A Lepland… - medRxiv, 2024 - medrxiv.org
Breast cancer (BC) remains the most common malignant tumor site and the leading cause of
cancer-related deaths in women despite the wide availability of screening programs and …

[PDF][PDF] Guidance for the Clinical Use of the Breast Cancer Polygenic Risk Score

P Padrik, N Tõnisson, T Hovda, KK Sahlberg, E Hovig… - 2024 - preprints.org
Background/Objectives: Polygenic risk scores (PRSs) have been extensively studied and
are increasingly applied in healthcare. One of the most studied and developed areas is …

Precision Omics Initiative Sweden (PROMISE): A New Model for Biomedical Research

A Kämpe, S Gudmundsson, C Walsh, K Lindblad-Toh… - 2024 - papers.ssrn.com
Biomedical research and its applications in healthcare are undergoing exponential growth,
fueled by a global commitment to improve human health through advanced genomics and …

[PDF][PDF] Population‐specific validation and comparison of the performance of 77‐and 313‐variant polygenic risk scores for breast cancer risk prediction

MD Lenka Foretova, MD Marta Kalousova… - 2024 - researchgate.net
Background: The polygenic risk score (PRS) allows the quantification of the polygenic effect
of many low‐penetrance alleles on the risk of breast cancer (BC). This study aimed to …