Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Our understanding of the complex molecular processes of living organisms at the molecular
level is growing exponentially. This knowledge, together with a powerful arsenal of tools for …

The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …

Over the past two decades, genetic code expansion (GCE)-enabled methods for
incorporating noncanonical amino acids (ncAAs) into proteins have significantly advanced …

With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …

Thiopeptides (also known as thiazolyl peptides) are structurally complex natural products
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …

Thiopeptides are a class of natural product antibiotics with diverse structures and functions.
Their complex structures and biosynthesis have intrigued researchers since their discovery …

The emergence of antimicrobial resistance is a global health concern and calls for the
development of novel antibiotic agents. Antimicrobial peptides seem to be promising …

The ability to site-specifically incorporate noncanonical amino acids (ncAAs) with novel
structures into proteins in living cells affords a powerful tool to investigate and manipulate …

Lactazole A is a cryptic thiopeptide from Streptomyces lactacystinaeus, encoded by a
compact 9.8 kb biosynthetic gene cluster. Here, we establish a platform for in vitro …