Targeting angiogenesis in oncology, ophthalmology and beyond

Y Cao, R Langer, N Ferrara - Nature Reviews Drug Discovery, 2023 - nature.com
Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

Polypoidal choroidal vasculopathy: definition, pathogenesis, diagnosis, and management

CMG Cheung, TYY Lai, P Ruamviboonsuk, SJ Chen… - Ophthalmology, 2018 - Elsevier
Polypoidal choroidal vasculopathy (PCV) is an age-related macular degeneration (AMD)
subtype and is seen particularly in Asians. Previous studies have suggested disparity in …

Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration

KS Lee, S Lin, DA Copland, AD Dick, J Liu - Journal of Neuroinflammation, 2021 - Springer
Age-related macular degeneration (AMD), a degenerative disease in the central macula
area of the neuroretina and the supporting retinal pigment epithelium, is the most common …

Mechanisms of age‐related macular degeneration and therapeutic opportunities

M van Lookeren Campagne, J LeCouter… - The Journal of …, 2014 - Wiley Online Library
As the age of the population increases in many nations, age‐related degenerative diseases
pose significant socioeconomic challenges. One of the key degenerative diseases that …

Age-related macular degeneration and polypoidal choroidal vasculopathy in Asians

CW Wong, Y Yanagi, WK Lee, Y Ogura, I Yeo… - Progress in retinal and …, 2016 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
elderly people globally. It is estimated that there will be more Asians with AMD than the rest …

Astrocytes and aging

AL Palmer, SS Ousman - Frontiers in Aging Neuroscience, 2018 - frontiersin.org
By 2050, the aging population is predicted to expand by over 100%. Considering this rapid
growth, and the additional strain it will place on healthcare resources because of age …

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma

K Zhang, L Zhang, RN Weinreb - Nature reviews Drug discovery, 2012 - nature.com
Blindness affects 60 million people worldwide. The leading causes of irreversible blindness
include age-related macular degeneration, retinal vascular diseases and glaucoma. The …

Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy

SS Whitmore, EH Sohn, KR Chirco, AV Drack… - Progress in retinal and …, 2015 - Elsevier
Age-related macular degeneration (AMD) is a common and devastating disease that can
result in severe visual dysfunction. Over the last decade, great progress has been made in …

Age-related macular degeneration revisited–piecing the puzzle: the LXIX Edward Jackson memorial lecture

JW Miller - American journal of ophthalmology, 2013 - Elsevier
PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

Complement cascade inhibition in geographic atrophy: a review

D Desai, PU Dugel - Eye, 2022 - nature.com
The pathophysiology of dry age-related macular degeneration (AMD) and specifically
geographic atrophy (GA) has been linked to the complement cascade. This cascade is part …