Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential
TY Zhu, LL Hong, ZQ Ling - Biomarker research, 2023 - Springer
Abstract N6-methyladenosine (m6A) is the most prevalent and well-characterized internal
chemical modification in eukaryotic RNA, influencing gene expression and phenotypic …
chemical modification in eukaryotic RNA, influencing gene expression and phenotypic …
[HTML][HTML] Regulatory mechanisms and therapeutic implications of insulin-like growth factor 2 mRNA-binding proteins, the emerging crucial m6A regulators of tumors
H Zhou, Q Sun, M Feng, Z Gao, S Jia, L Cao, X Yu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) serve essential biological
functions as post-transcriptional performers, participating in the acquisition or maintenance …
functions as post-transcriptional performers, participating in the acquisition or maintenance …
TRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell …
Y Xu, L Li, W Yang, K Zhang, Z Zhang, C Yu… - Journal of Experimental …, 2023 - Springer
Background The management of advanced clear cell renal cell carcinoma (ccRCC) remains
a major challenge in clinical practice, and the construction of more reliable prognostic …
a major challenge in clinical practice, and the construction of more reliable prognostic …
[HTML][HTML] N6-methyladenosine (m6A) methylation in kidney diseases: Mechanisms and therapeutic potential
Y Sun, D Jin, Z Zhang, H Ji, X An, Y Zhang… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Abstract The N6-methyladenosine (m6A) modification is regulated by methylases, commonly
referred to as “writers,” and demethylases, known as “erasers,” leading to a dynamic and …
referred to as “writers,” and demethylases, known as “erasers,” leading to a dynamic and …
[HTML][HTML] Novel insights into the roles of N6-methyladenosine (m6A) modification and autophagy in human diseases
J Liang, J Sun, W Zhang, X Wang, Y Xu… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Autophagy is an evolutionarily conserved cellular degradation and recycling process. It is
important for maintaining vital cellular function and metabolism. Abnormal autophagy activity …
important for maintaining vital cellular function and metabolism. Abnormal autophagy activity …
N6-methyladenosine methylation in kidney injury
Q Wang, X Fan, Q Sheng, M Yang, P Zhou, S Lu… - Clinical …, 2023 - Springer
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic
modifications in the occurrence and development of kidney diseases is constantly being …
modifications in the occurrence and development of kidney diseases is constantly being …
[HTML][HTML] Novel insights into the interplay between m6A modification and programmed cell death in cancer
J Chen, M Ye, J Bai, C Hu, F Lu, D Gu… - International journal of …, 2023 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA
modification in eukaryotes, has recently become a hot research topic. Several studies have …
modification in eukaryotes, has recently become a hot research topic. Several studies have …
Knockdown of ADAM8 inhibits the proliferation, migration, invasion, and tumorigenesis of renal clear cell carcinoma cells to enhance the immunotherapy efficacy
H Qu, M Mao, K Wang, Z Mu, B Hu - Translational Research, 2024 - Elsevier
The current study performed bioinformatics and in vitro and in vivo experiments to explore
the effects of ADAM8 on the malignant behaviors and immunotherapeutic efficacy of renal …
the effects of ADAM8 on the malignant behaviors and immunotherapeutic efficacy of renal …
[HTML][HTML] The potential role of RNA modification in skin diseases, as well as the recent advances in its detection methods and therapeutic agents
Y Yu, C Liang, X Wang, Y Shi, L Shen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
RNA modification is considered as an epigenetic modification that plays an indispensable
role in biological processes such as gene expression and genome editing without altering …
role in biological processes such as gene expression and genome editing without altering …
Nucleic acid and protein methylation modification in renal diseases
J Jin, X Liu, W Shao, X Meng - Acta Pharmacologica Sinica, 2024 - nature.com
Although great efforts have been made to elucidate the pathological mechanisms of renal
diseases and potential prevention and treatment targets that would allow us to retard kidney …
diseases and potential prevention and treatment targets that would allow us to retard kidney …