Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst.
ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as …

Octamer-binding transcription factor 3/4 (OCT-3/4), which is involved in the tumorigenesis of
somatic cancers, has diverse functions during cancer development. Overexpression of OCT …

Background: Chemotherapeutic resistance of glioblastoma has been attributed to a self-
renewing subpopulation, the glioma stem cells (GSCs), which is known to be maintained by …

ABSTRACT O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential
enzyme that modifies proteins with O-GlcNAc. Inborn OGT genetic variants were recently …

Transcription factor-driven cell fate engineering in pluripotency induction,
transdifferentiation, and forward reprogramming requires efficiency, speed, and maturity for …

Nitro-oleic acid (NO2-OA), pluripotent cell-signaling mediator, was recently described as a
modulator of the signal transducer and activator of transcription 3 (STAT3) activity. In our …

O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential enzyme that
modifies proteins with O-GlcNAc. Inborn OGT genetic variants were recently shown to …

Embryonic stem cells (ESCs) isolated from the inner cell mass of the blastocyst have the
ability to self-renew and to differentiate into all three germ layers. Due to these properties …

Pluripotent stem cells within the inner cell mass and epiblast of mammalian embryos have
the capacity to form all lineages in the adult organism, while multipotent trophoblast stem …

Pluripotent mouse embryonic stem (ES) cells, which are derived from the inner cell mass
(ICM) of preimplantation stage embryos, are capable of self-renewing indefinitely in the …