Gene therapy has been experiencing a breakthrough in recent years, targeting various
specific cell groups in numerous therapeutic areas. However, most recent clinical studies …

The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

The refractory diabetic wound has remained a worldwide challenge as one of the major
health problems. The impaired angiogenesis phase during diabetic wound healing partly …

Gene therapy holds great promise for treating a multitude of inherited and acquired diseases
by delivering functional genes, comprising DNA or RNA, into targeted cells or tissues to elicit …

Endosomal escape remains a fundamental barrier hindering the advancement of nucleic
acid therapeutics. Taking inspiration from natural phospholipids that comprise biological …

Polymers represent a promising therapeutic platform for extrahepatic messenger RNA
(mRNA) delivery but are hampered by low in vivo efficacy due to polyplex serum instability …

Biotherapy has recently become a hotspot research topic with encouraging prospects in
various fields due to a wide range of treatments applications, as demonstrated in preclinical …

Cytosolic protein delivery is a prerequisite for protein‐based biotechnologies and
therapeutics on intracellular targets. Polymers that can complex with proteins to form nano …

Regulation of CRISPR-Cas9 functions in vivo is conducive to developing precise therapeutic
genome editing. Here, we report a CRISPR-Cas9 prodrug nanosystem (termed …

Nanotechnology-based antitumor drug delivery systems, known as nanocarriers, have
demonstrated their efficacy in recent years. Typically, the size of the nanocarriers is around …