Chloride transport modulators as drug candidates

AS Verkman, LJV Galietta - American Journal of Physiology …, 2021 - journals.physiology.org
Chloride transport across cell membranes is broadly involved in epithelial fluid transport, cell
volume and pH regulation, muscle contraction, membrane excitability, and organellar …

Qingwenzhike Prescription Alleviates Acute Lung Injury Induced by LPS via Inhibiting TLR4/NF-kB Pathway and NLRP3 Inflammasome Activation

C Zhang, X Wang, C Wang, C He, Q Ma, J Li… - Frontiers in …, 2021 - frontiersin.org
Background: Acute lung injury (ALI) is characterized by dysfunction of the alveolar epithelial
membrane caused by acute inflammation and tissue injury. Qingwenzhike (QWZK) …

[HTML][HTML] Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis

M Sinha, D Zabini, D Guntur, C Nagaraj… - Pharmacology & …, 2022 - Elsevier
Fine control over chloride homeostasis in the lung is required to maintain membrane
excitability, transepithelial transport as well as intra-and extracellular ion and water …

Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress

Q Wu, C Liu, D Liu, Y Wang, H Qi, X Liu… - Science of The Total …, 2024 - Elsevier
It has been shown that exposure to nanoplastics (MNPs) through inhalation can induce
pulmonary toxicity, but the toxicological mechanism of MNPs on the respiratory system …

Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation

X Zhang, D Wu, Y Tian, X Chen, J Lan, F Wei… - Pharmaceutical …, 2022 - Taylor & Francis
Context Ganoderma lucidum polysaccharides (GLP), from Ganoderma lucidum (Leyss. ex
Fr.) Karst.(Ganodermataceae), are reported to have anti-inflammatory effects, including anti …

Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling

Y Tu, J Liu, D Kong, X Guo, J Li, Z Long, J Peng… - Free Radical Biology …, 2023 - Elsevier
Irisin is an exercise-induced myokine that alleviates inflammation and obesity. The induction
of anti-inflammatory (M2) macrophage is facilitated for treatment of sepsis and associated …

De Novo Design of Activatable Photoacoustic/Fluorescent Probes for Imaging Acute Lung Injury In Vivo

XP Fan, J Huang, TB Ren, L Yuan… - Analytical …, 2022 - ACS Publications
Effective monitoring of the physiological progression of acute lung injury (ALI) in real time is
crucial for early theranostics to reduce its high mortality. In particular, activatable …

[HTML][HTML] Intrinsically bioactive multifunctional Poly (citrate-curcumin) for rapid lung injury and MRSA infection therapy

T Leng, L Zhang, J Ma, X Qu, B Lei - Bioactive Materials, 2024 - Elsevier
Dysregulated inflammation after trauma or infection could result in the further disease and
delayed tissue reconstruction. The conventional anti-inflammatory drug treatment suffers to …

Type I Cystatin Derived from Fasciola gigantica Suppresses Macrophage-Mediated Inflammatory Responses

P Chantree, M Tarasuk, P Prathaphan, J Ruangtong… - Pathogens, 2023 - mdpi.com
There is an inverse relationship between the high incidence of helminth infection and the
low incidence of inflammatory disease. Hence, it may be that helminth molecules have anti …

[HTML][HTML] Airway surface hyperviscosity and defective mucociliary transport by IL-17/TNF-α are corrected by β-adrenergic stimulus

D Guidone, M Buccirossi, P Scudieri, M Genovese… - JCI insight, 2022 - ncbi.nlm.nih.gov
The fluid covering the surface of airway epithelia represents a first barrier against
pathogens. The chemical and physical properties of the airway surface fluid are controlled …