Roles of pH in control of cell proliferation

M Flinck, SH Kramer, SF Pedersen - Acta Physiologica, 2018 - Wiley Online Library
Precise spatiotemporal regulation of intracellular pH (pH i) is a prerequisite for normal cell
function, and changes in pH i or pericellular pH (pH e) exert important signalling functions. It …

[HTML][HTML] ChatGPT and the rise of generative AI: Threat to academic integrity?

DO Eke - Journal of Responsible Technology, 2023 - Elsevier
The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases

S Harguindey, D Stanciu, J Devesa, K Alfarouk… - Seminars in cancer …, 2017 - Elsevier
During the last few years, the understanding of the dysregulated hydrogen ion dynamics and
reversed proton gradient of cancer cells has resulted in a new and integral pH-centric …

Targeting pH regulating proteins for cancer therapy–Progress and limitations

SK Parks, J Pouysségur - Seminars in cancer biology, 2017 - Elsevier
Tumour acidity induced by metabolic alterations and incomplete vascularisation sets cancer
cells apart from normal cellular physiology. This distinguishing tumour characteristic has …

Structural and Functional Changes in the Na+/H+ Exchanger Isoform 1, Induced by Erk1/2 Phosphorylation

L Fliegel - International journal of molecular sciences, 2019 - mdpi.com
The human Na+/H+ exchanger isoform 1 (NHE1) is a plasma membrane transport protein
that plays an important role in pH regulation in mammalian cells. Because of the generation …

[HTML][HTML] Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus

L Sobrevia, P Valero, A Grismaldo… - … Et Biophysica Acta (BBA …, 2020 - Elsevier
Gestational diabetes mellitus (GDM) is a disease of pregnancy that is associated with d-
glucose intolerance and foeto-placental vascular dysfunction. GMD causes mitochondrial …

Emerging roles for ion channels in ovarian cancer: Pathomechanisms and pharmacological treatment

C Altamura, MR Greco, MR Carratù, RA Cardone… - Cancers, 2021 - mdpi.com
Simple Summary Around 4% of cancer deaths in the world was associated to ovarian cancer
(OC), making it the eighth most common cause of death in women. Increasing evidence …

Intracellular pH affects mitochondrial homeostasis in cultured human corneal endothelial cells prepared for cell injection therapy

H Deguchi, T Yamashita, N Hiramoto, Y Otsuki… - Scientific Reports, 2022 - nature.com
This study aimed to uncover the mechanism responsible for the clinical efficacy of cell
injection therapy with fully differentiated cultured cells. Analysis of polarized expression of …

[HTML][HTML] Dihydroartemisinin prompts amplification of photodynamic therapy-induced reactive oxygen species to exhaust Na/H exchanger 1-mediated glioma cells …

K Hou, J Liu, J Du, S Mi, S Ma, Y Ba, H Ji, B Li… - … of Photochemistry and …, 2021 - Elsevier
Photodynamic therapy (PDT) is a promising glioma therapy; however, its efficacy is
compromised due to the PDT-induced reactive oxygen species (ROS) production being …

Ginsenoside Rg3 Decreases NHE1 Expression via Inhibiting EGF-EGFR-ERK1/2-HIF-1 Pathway in Hepatocellular Carcinoma: A Novel Antitumor Mechanism

X Li, J Tsauo, C Geng, H Zhao, X Lei… - The American Journal of …, 2018 - World Scientific
Na+/H+ exchanger 1 (NHE1) plays a vital role in the oncogenesis and development of
hepatocellular carcinoma (HCC) and has been regarded as a promising target for the …