In the late 70's, the discovery of the restriction enzymes made possible the biological
production of functional proteins by recombinant DNA technologies, a fact that largely …

Cancer stem cells (CSCs) are a subpopulation of cells that can initiate, self-renew, and
sustain tumor growth. CSCs are responsible for tumor metastasis, recurrence, and drug …

Advanced medical treatments involving drug delivery require fully biocompatible materials
with the ability to release functional drugs in a time‐prolonged way. Ideally, the delivered …

The coordination between histidine-rich peptides and divalent cations supports the
formation of nano-and micro-scale protein biomaterials, including toxic and non-toxic …

The need for more effective and precision medicines for cancer has pushed the exploration
of new materials appropriate for drug delivery and imaging, and alternative receptors for …

Poly-histidine peptides such as H6 (HHHHHH) are used in protein biotechnologies as
purification tags, protein-assembling agents and endosomal-escape entities. The pleiotropic …

Five peptide ligands of four different cell surface receptors (nucleolin, CXCR1, CMKLR1,
and CD44v6) have been evaluated as targeting moieties for triple-negative human breast …

Protein venoms are effective cytotoxic molecules that when conveniently targeted to tumoral
markers can be exploited as promising anticancer drugs. Here, it is explored whether the …

Nanobodies represent valuable tools in advanced therapeutic strategies but their small size
(∼ 2.5×∼ 4 nm) and limited valence for interactions might pose restrictions for in vivo …

As the increasing number of the individuals suffering from AIDs, chemotherapy, and
radiotherapy, pathogenic fungi, which may rapidly grow and invade the host tissues in these …