BACKGROUND Meiosis is an essential stage in the life cycle of sexually reproducing
species, underlying formation of haploid gametes and serving as the basis of genetic …

Human spermatogenesis is a highly ordered process; however, the roles of DNA
methylation and chromatin accessibility in this process remain largely unknown. Here by …

Hydatidiform mole (HM) is an abnormal human pregnancy characterized by excessive
growth of placental trophoblasts and abnormal early embryonic development. Following a …

Human infertility is a multifactorial disease that affects 8%–12% of reproductive-aged
couples worldwide. However, the genetic causes of human infertility are still poorly …

Faithful segregation of X and Y chromosomes requires meiotic recombination to form a
crossover between them in the pseudoautosomal region (PAR). Unlike autosomes that have …

The DSB machinery, which induces the programmed DNA double-strand breaks (DSBs) in
the leptotene and zygotene stages during meiosis, is suppressed before the onset of the …

STUDY QUESTION Do variants in helicase for meiosis 1 (HFM1) account for male infertility
in humans? SUMMARY ANSWER Biallelic variants in HFM1 cause human male infertility …

Context Premature ovarian insufficiency (POI) and nonobstructive azoospermia (NOA) are
the most severe diseases causing irreversible infertility in females and males, respectively …

The meiosis-specific LINC complex, composed of the KASH5 and SUN1 proteins, tethers the
moving chromosomes to the nuclear envelope to facilitate homolog pairing and is essential …

Following meiotic recombination, each pair of homologous chromosomes acquires at least
one crossover, which ensures accurate chromosome segregation and allows reciprocal …