Endometriosis is a chronic systemic disease: clinical challenges and novel innovations

HS Taylor, AM Kotlyar, VA Flores - The Lancet, 2021 - thelancet.com
Endometriosis is a common disease affecting 5–10% of women of reproductive age globally.
However, despite its prevalence, diagnosis is typically delayed by years, misdiagnosis is …

The pathogenesis of endometriosis: molecular and cell biology insights

AS Laganà, S Garzon, M Götte, P Viganò… - International journal of …, 2019 - mdpi.com
The etiopathogenesis of endometriosis is a multifactorial process resulting in a
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …

Role of estrogen receptors in health and disease

P Chen, B Li, L Ou-Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

Hormonal treatments for endometriosis: The endocrine background

S Vannuccini, S Clemenza, M Rossi… - Reviews in Endocrine and …, 2022 - Springer
Endometriosis is a benign uterine disorder characterized by menstrual pain and infertility,
deeply affecting women's health. It is a chronic disease and requires a long term …

The origin and pathogenesis of endometriosis

Y Wang, K Nicholes, IM Shih - Annual Review of Pathology …, 2020 - annualreviews.org
Recent molecular genetic findings on endometriosis and normal endometrium suggest a
modified model in which circulating epithelial progenitor or stem cells intended to …

Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis?

RM Marquardt, TH Kim, JH Shin, JW Jeong - International journal of …, 2019 - mdpi.com
In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly
regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo …

Endometrial receptivity in women of advanced age: an underrated factor in infertility

ADS Pathare, M Loid, M Saare, SB Gidlöf… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced
age is one of the critical risk factors for female-related infertility. It is well known that maternal …

Endometriosis: pathogenesis and treatment

P Vercellini, P Viganò, E Somigliana… - Nature Reviews …, 2014 - nature.com
Endometriosis is defined as the presence of endometrial-type mucosa outside the uterine
cavity. Of the proposed pathogenic theories (retrograde menstruation, coelomic metaplasia …

Adenomyosis pathogenesis: insights from next-generation sequencing

SE Bulun, S Yildiz, M Adli, JJ Wei - Human Reproduction Update, 2021 - academic.oup.com
BACKGROUND Adenomyosis, characterized by the presence of islands of endometrial
tissue surrounded by hypertrophic smooth muscle cells within the myometrium, is one of the …

Progesterone resistance in endometriosis: origins, consequences and interventions

BG Patel, M Rudnicki, J Yu, Y Shu… - Acta obstetricia et …, 2017 - Wiley Online Library
Endometriosis is a common cause of pelvic pain and affects up to 10% of women of
reproductive age. Aberrant progesterone signaling in the endometrium plays a significant …