Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …

Background Multiple sclerosis is an acquired demyelinating disease of the central nervous
system. It is the second most common cause of disability in adults in United States after head …

Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a member of the hnRNP family
of conserved proteins that is involved in RNA transcription, pre-mRNA splicing, mRNA …

Identification of the target antigens of pathogenic antibodies and T cells is of fundamental
importance for understanding the pathogenesis of multiple sclerosis, and for the …

Multiple sclerosis (MS) is considered a prototypic autoimmune disease of the central
nervous system (CNS). A complex genetic background with the HLA-DR15 haplotype as the …

One hypothesis that couples infection with autoimmune disease is molecular mimicry.
Molecular mimicry is characterized by an immune response to an environmental agent that …

Glatiramer acetate (GA, Copaxone [Teva Pharmaceuticals, Kansas City, MO], formerly
known as copolymer-1) and interferon-(IFN)-β are both used for the immunomodulatory …

Autoimmune T and B cell responses to CNS antigen (s) are thought to drive the
pathogenesis of multiple sclerosis (MS), and thus are logical targets for therapy. Indeed …

A variety of cellular and humoral immunological abnormalities have been observed in
multiple sclerosis (MS). In the past few years, several lines of evidence converged to imply …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system white
matter. The association of the disease with MHC genes, the inflammatory white matter …