The alteration and aggregation of alpha-synuclein (α-syn) play a crucial role in
neurodegenerative diseases collectively termed as synucleinopathies, including Parkinson's …

Synaptotagmin-1 is a low-affinity Ca2+ sensor that triggers synchronous vesicle fusion. It
contains two similar C2 domains (C2A and C2B) that cooperate in membrane binding, being …

α-Synuclein is an intrinsically disordered protein abundant in presynaptic terminals in
neurons and in synaptic vesicles. α-Synuclein's interaction with lipid bilayers is important not …

The fusion pore controls the release of exocytotic vesicle contents through a precise
orchestration of lipids from the fusing membranes and proteins. There is a major lipid …

Today, it is widely accepted that intrinsic disorder is strongly related to the cell cycle, during
mitosis, differentiation, and apoptosis. Of particular interest are hybrid proteins possessing …

Fusion pores serve as an effective mechanism to connect intracellular organelles and
release vesicle contents during exocytosis. A complex lipid rearrangement takes place as …

The sperm acrosome is a large dense-core granule whose contents are secreted by
regulated exocytosis at fertilization through the opening of numerous fusion pores between …

Membrane fusion is a crucial mechanism in a wide variety of important events in cell biology
from viral infection to exocytosis. However, despite many efforts and much progress, cell …

The α-Synuclein (α-Syn) plays an important role in the pathology of Parkinson's disease
(PD), and its oligomers and fibrils are toxic to the nervous system. As organisms age, the …

The tetraspanin family plays key roles in many physiological processes, such as, tumour
invasion, cell motility, virus infection, cell attachment and entry. Tetraspanins function as …