Live porcine reproductive and respiratory syndrome virus vaccines: current status and future direction

GJ Renukaradhya, XJ Meng, JG Calvert, M Roof… - Vaccine, 2015 - Elsevier
Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV)
was reported in the late 1980s. PRRS still is a huge economic concern to the global pig …

Nanoparticle-based vaccine development and evaluation against viral infections in pigs

S Dhakal, GJ Renukaradhya - Veterinary research, 2019 - Springer
Virus infections possess persistent health challenges in swine industry leading to severe
economic losses worldwide. The economic burden caused by virus infections such as …

Serum-derived exosomes from non-viremic animals previously exposed to the porcine respiratory and reproductive virus contain antigenic viral proteins

S Montaner-Tarbes, FE Borrás, M Montoya, L Fraile… - Veterinary …, 2016 - Springer
PRRSV is the etiological agent of one of the most important swine diseases with a significant
economic burden worldwide and limitations in vaccinology. Exosomes are 30–100 nm …

An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted …

B Binjawadagi, V Dwivedi, C Manickam… - International journal …, 2014 - Taylor & Francis
Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating
respiratory disease of pigs. The disease is caused by the PRRS virus (PRRSV), an …

Mutations in a highly conserved motif of nsp1β protein attenuate the innate immune suppression function of porcine reproductive and respiratory syndrome virus

Y Li, DL Shyu, P Shang, J Bai, K Ouyang… - Journal of …, 2016 - Am Soc Microbiol
Porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein 1β
(nsp1β) is a multifunctional viral protein, which is involved in suppressing the host innate …

Intranasal delivery of inactivated PRRSV loaded cationic nanoparticles coupled with enterotoxin subunit B induces PRRSV-specific immune responses in pigs

P Chaikhumwang, A Madapong, K Saeng-Chuto… - Scientific Reports, 2022 - nature.com
This study was conducted to evaluate the induction of systemic and mucosal immune
responses and protective efficacy following the intranasal administration of inactivated …

Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs

V Dwivedi, C Manickam, B Binjawadagi, D Joyappa… - PLoS …, 2012 - journals.plos.org
Biodegradable nanoparticle-based vaccine development research is unexplored in large
animals and humans. In this study, we illustrated the efficacy of nanoparticle-entrapped UV …

Poly d, l-lactide-co-glycolide (PLGA) nanoparticle-encapsulated honeybee (Apis melifera) venom promotes clearance of Salmonella enterica serovar Typhimurium …

JA Lee, BG Jung, TH Kim, YM Kim, MH Park… - Veterinary Immunology …, 2014 - Elsevier
Honeybee (Apis melifera) venom (HBV), which includes melittin and lipid-soluble
ingredients (chrysin and pinocembrin), elicited increases in the CD4+/CD8+ T lymphocyte …

A Comprehensive Review of Our Understanding and Challenges of Viral Vaccines against Swine Pathogens

A Kamboj, S Dumka, MK Saxena, Y Singh, BP Kaur… - Viruses, 2024 - mdpi.com
Pig farming has become a strategically significant and economically important industry
across the globe. It is also a potentially vulnerable sector due to challenges posed by …

Adjuvant effects of invariant NKT cell ligand potentiates the innate and adaptive immunity to an inactivated H1N1 swine influenza virus vaccine in pigs

V Dwivedi, C Manickam, S Dhakal, B Binjawadagi… - Veterinary …, 2016 - Elsevier
Pigs are considered as the source of some of the emerging human flu viruses. Inactivated
swine influenza virus (SwIV) vaccine has been in use in the US swine herds, but it failed to …