Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …

Alzheimer's disease (AD) is a neurodegenerative disorder influenced by a complex interplay
of environmental, epigenetic, and genetic factors. DNA methylation (5mC) and …

The three mammalian TET dioxygenases oxidize the methyl group of 5-methylcytosine in
DNA, and the oxidized methylcytosines are essential intermediates in all known pathways of …

The establishment of cellular identity is driven by transcriptional and epigenetic regulators of
the chromatin proteome-the chromatome. Comprehensive analyses of the chromatome …

Enzymes of the ten-eleven translocation (TET) family play a key role in the regulation of
gene expression by oxidizing 5-methylcytosine (5mC), a prominent epigenetic mark in many …

Gastrulation begins when the epiblast forms the primitive streak or becomes definitive
ectoderm. During this lineage bifurcation, the DNA dioxygenase TET1 has bipartite functions …

Chromatin is a vital and dynamic structure that is carefully regulated to maintain proper cell
homeostasis. A great deal of this regulation is dependent on histone proteins which have the …

Mass spectrometry-based omics technologies are increasingly used in perturbation studies
to map drug effects to biological pathways by identifying significant molecular events …