The biology and functional importance of MAIT cells

DI Godfrey, HF Koay, J McCluskey, NA Gherardin - Nature immunology, 2019 - nature.com
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …

MAIT cells: new guardians of the liver

A Kurioka, LJ Walker, P Klenerman… - Clinical & translational …, 2016 - Wiley Online Library
The liver is an important immunological organ that remains sterile and tolerogenic in
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …

Human blood MAIT cell subsets defined using MR1 tetramers

NA Gherardin, MNT Souter, HF Koay… - Immunology and cell …, 2018 - Wiley Online Library
Mucosal‐associated invariant T (MAIT) cells represent up to 10% of circulating human T
cells. They are usually defined using combinations of non‐lineage‐specific (surrogate) …

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines

J Dias, E Leeansyah… - Proceedings of the …, 2017 - National Acad Sciences
Mucosa-associated invariant T (MAIT) cells are a large innate-like T-cell subset in humans
defined by invariant TCR Vα7. 2 use and expression of CD161. MAIT cells recognize …

A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa

O Jensen, S Trivedi, JD Meier, KC Fairfax, JS Hale… - Science …, 2022 - science.org
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that aid in
protection against bacterial pathogens at mucosal surfaces through the release of …

Ontogeny of human mucosal-associated invariant T cells and related T cell subsets

G Ben Youssef, M Tourret, M Salou… - Journal of Experimental …, 2018 - rupress.org
Mucosal-associated invariant T (MAIT) cells are semi-invariant Vα7. 2+ CD161highCD4− T
cells that recognize microbial riboflavin precursor derivatives such as 5-OP-RU presented by …

[HTML][HTML] MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity

TE Pankhurst, KH Buick, JL Lange, AJ Marshall… - Cell Reports, 2023 - cell.com
Protective immune responses against respiratory pathogens, such as severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the …

The immunology of CD1-and MR1-restricted T cells

L Mori, M Lepore, G De Libero - Annual review of immunology, 2016 - annualreviews.org
CD1-and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …

[HTML][HTML] Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation

C Tastan, E Karhan, W Zhou, E Fleming, AY Voigt… - Mucosal …, 2018 - Elsevier
Human mucosal-associated invariant T (MAIT) cell receptors (TCRs) recognize bacterial
riboflavin pathway metabolites through the MHC class 1-related molecule MR1. However, it …

[HTML][HTML] MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A

LJ Howson, G Napolitani, D Shepherd… - Nature …, 2018 - nature.com
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can detect bacteria-
derived metabolites presented on MR1. Here we show, using a controlled infection of …