Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

Countless times each day, the acute inflammatory response protects us from invading
microbes, injuries, and insults from within, as in surgery-induced tissue injury. These …

The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …

The prevalence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, yet there
are no effective treatments. A decade has passed since the initial lipidomics analyses of liver …

Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with
excessive deposition of extracellular matrix and connective tissue at the site of injury. In this …

Prospective observational studies support the use of long-chain omega-3 polyunsaturated
fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; …

Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting up to 30% of the
general adult population. NAFLD encompasses a histological spectrum ranging from pure …

Recent studies have identified a genetic variant rs641738 near two genes encoding
membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transmembrane …

Variation in levels of the human metabolome reflect changes in homeostasis, providing a
window into health and disease. The genetic impact on circulating metabolites in Hispanics …