Neuroinflammation is a central mechanism involved in neurodegeneration as observed in
Alzheimer's disease (AD), the most prevalent form of neurodegenerative disease …

Abstract The original Human Connectome Project yielded a rich data set on structural and
functional connectivity in a large sample of healthy young adults using improved methods of …

Animal studies suggest that the apolipoprotein E ε4 (APOE ε4) allele is a culprit of early
microglial activation in Alzheimer's disease (AD). Here, we tested the association between …

Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …

Hippocampal atrophy, as evidenced using magnetic resonance imaging (MRI), is one of the
most validated, easily accessible and widely used biomarkers of Alzheimer's disease (AD) …

While aggregation of neuroimaging datasets from multiple sites and scanners can yield
increased statistical power, it also presents challenges due to systematic scanner effects …

Importance Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for
Alzheimer disease. WhileAPOEε4is associated with increased amyloid-β burden, its …

Neurodegenerative disorders leading to dementia are common diseases that affect many
older and some young adults. Neuroimaging methods are important tools for assessing and …

Diagnosis of Alzheimer's disease (AD) in its earliest stages becomes increasingly important
as disease modifying agents are being developed. In this area of research, many clinical …

The goal of this review is to provide an overview of biomarkers for Alzheimer's disease (AD),
with emphasis on neuroimaging and cerebrospinal fluid (CSF) biomarkers. We first review …