Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance—A review

RK Saini, YS Keum - Life sciences, 2018 - Elsevier
Abstract Linoleic acid (LA)(n− 6) and α-linolenic acid (ALA)(n− 3) are essential fatty acids
(EFAs) as they cannot be synthesized by humans or other higher animals. In the human …

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

CN Serhan, N Chiang, J Dalli - Seminars in immunology, 2015 - Elsevier
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …

[HTML][HTML] Advances in our understanding of oxylipins derived from dietary PUFAs

M Gabbs, S Leng, JG Devassy, M Monirujjaman… - Advances in …, 2015 - Elsevier
Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …

Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials

SF Nabavi, S Bilotto, GL Russo, IE Orhan… - Cancer and Metastasis …, 2015 - Springer
Over the past decades, extensive studies have addressed the therapeutic effects of omega-3
polyunsaturated fatty acids (omega-3 FAs) against different human diseases such as …

Metabolism-based therapeutic strategies targeting cancer stem cells

P Jagust, B de Luxán-Delgado… - Frontiers in …, 2019 - frontiersin.org
Cancer heterogeneity constitutes the major source of disease progression and therapy
failure. Tumors comprise functionally diverse subpopulations, with cancer stem cells (CSCs) …

ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer

W Wang, J Zhu, F Lyu, D Panigrahy, KW Ferrara… - Prostaglandins & other …, 2014 - Elsevier
Epidemiological and pre-clinical studies support the anti-tumor effects of ω-3 PUFAs;
however, the results from human trials are mixed, making it difficult to provide dietary …

Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine

KC Nicolaou, S Rigol - Natural product reports, 2020 - pubs.rsc.org
Covering: 1970 to 2020 By definition total synthesis is the art and science of making the
molecules of living Nature in the laboratory, and by extension, their analogues. Although …

The expansive role of oxylipins on platelet biology

J Yeung, M Hawley, M Holinstat - Journal of molecular medicine, 2017 - Springer
In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and
cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) …

Omega-3 polyunsaturated fatty acids and cancer

K Jing, T Wu, K Lim - Anti-Cancer Agents in Medicinal …, 2013 - ingentaconnect.com
While the anticancer effect of omega-3 polyunsaturated fatty acids (omega-3 fatty acids),
particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been the …

The metabolic heterogeneity and flexibility of cancer stem cells

A Tanabe, H Sahara - Cancers, 2020 - mdpi.com
Simple Summary Cancer stem cells (CSCs) have been shown to be the main cause of
therapy resistance and cancer recurrence. An analysis of their biological properties has …