[HTML][HTML] Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration
Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …
attention as a way to better mimic the complex interactions between individual cells and the …
Modulation of the inflammatory response and bone healing
M Maruyama, C Rhee, T Utsunomiya… - Frontiers in …, 2020 - frontiersin.org
The optimal treatment for complex fractures and large bone defects is an important unsolved
issue in orthopedics and related specialties. Approximately 5–10% of fractures fail to heal …
issue in orthopedics and related specialties. Approximately 5–10% of fractures fail to heal …
Vascularization strategies in bone tissue engineering
F Simunovic, G Finkenzeller - Cells, 2021 - mdpi.com
Bone is a highly vascularized tissue, and its development, maturation, remodeling, and
regeneration are dependent on a tight regulation of blood vessel supply. This condition also …
regeneration are dependent on a tight regulation of blood vessel supply. This condition also …
Engineering multi‐cellular spheroids for tissue engineering and regenerative medicine
Multi‐cellular spheroids are formed as a 3D structure with dense cell–cell/cell–extracellular
matrix interactions, and thus, have been widely utilized as implantable therapeutics and …
matrix interactions, and thus, have been widely utilized as implantable therapeutics and …
Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells
Considering the unique therapeutic potential of mesenchymal stem cells (MSCs), including
their immunosuppressive and immunomodulatory properties as well as their ability to …
their immunosuppressive and immunomodulatory properties as well as their ability to …
Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling
Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …
address defects arising from trauma, inefficient wound repair, or congenital malformation …
Engineering the MSC secretome: a hydrogel focused approach
The therapeutic benefits of exogenously delivered mesenchymal stromal/stem cells (MSCs)
have been largely attributed to their secretory properties. However, clinical translation of …
have been largely attributed to their secretory properties. However, clinical translation of …
Hydrogel mechanics are a key driver of bone formation by mesenchymal stromal cell spheroids
J Whitehead, KH Griffin, M Gionet-Gonzales… - Biomaterials, 2021 - Elsevier
Mesenchymal stromal cells (MSCs) can promote tissue repair in regenerative medicine, and
their therapeutic potential is further enhanced via spheroid formation. Stress relaxation of …
their therapeutic potential is further enhanced via spheroid formation. Stress relaxation of …
Understanding and leveraging cell metabolism to enhance mesenchymal stem cell transplantation survival in tissue engineering and regenerative medicine …
GE Salazar-Noratto, G Luo, C Denoeud, M Padrona… - Stem Cells, 2020 - academic.oup.com
In tissue engineering and regenerative medicine, stem cell—specifically, mesenchymal
stromal/stem cells (MSCs)—therapies have fallen short of their initial promise and hype. The …
stromal/stem cells (MSCs)—therapies have fallen short of their initial promise and hype. The …
Engineered Cell‐Secreted Extracellular Matrix Modulates Cell Spheroid Mechanosensing and Amplifies Their Response to Inductive Cues for the Formation of …
T Gonzalez‐Fernandez, AJ Tenorio… - Advanced …, 2022 - Wiley Online Library
The clinical translation of mesenchymal stromal cell (MSC)‐based therapies remains
challenging due to rapid cell death and poor control over cell behavior. Compared to …
challenging due to rapid cell death and poor control over cell behavior. Compared to …