We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …

Context Somatic mutations have been identified in more than half of aldosterone-producing
adenomas (APAs) through mutation hotspot sequencing. The underlying pathogenesis of …

The identification of several germline and somatic ion channel mutations in aldosterone-
producing adenomas (APAs) and detection of cell clusters that can be responsible for …

Approximately one-tenth of the general population exhibit adrenal cortical nodules, and the
incidence has increased. Afflicted patients display a multifaceted symptomatology …

The purpose of this study was to synthesize a fluorine-18 labeled, highly selective
aldosterone synthase (h CYP11B2) inhibitor,[18F] AldoView, and to assess its potential for …

Unilateral primary aldosteronism (PA) is the most common surgically curable form of
hypertension that must be accurately differentiated from bilateral PA for therapeutic …

Primary aldosteronism is a secondary hypertensive disease caused by autonomous
aldosterone production that often caused by an aldosterone-producing adenoma (APA) …

Context The adrenal cortex consists of zona glomerulosa (ZG), fasciculata (ZF), and
reticularis. Aldosterone-producing cell clusters (APCCs) that strongly express aldosterone …

Primary aldosteronism (PA) can be sporadic or familial and classified into unilateral and
bilateral forms. Sporadic PA predominates with excessive aldosterone production usually …