This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Sleep is critical for diverse aspects of brain function in animals ranging from invertebrates to
humans. Powerful genetic tools in the fruit fly Drosophila melanogaster have identified—at …

Many different functions are regulated by circadian rhythms, including those orchestrated by
discrete clock neurons within animal brains. To comprehensively characterize and assign …

Neuropeptides are by far the largest and most diverse group of signaling molecules in
multicellular organisms. They are ancient molecules important in regulating a multitude of …

Plasticity in animal behaviour relies on the ability to integrate external and internal cues from
the changing environment and hence modulate activity in synaptic circuits of the brain. This …

Feeding and sleep are fundamental behaviours with significant interconnections and cross-
modulations. The circadian system and peptidergic signals are important components of this …

A sensitivity of the circadian clock to light/dark cycles ensures that biological rhythms
maintain optimal phase relationships with the external day. In animals, the circadian clock …

FMRFamides are evolutionarily conserved neuropeptides that play critical roles in behavior,
energy balance, and reproduction. Here, we show that FMRFamide signaling from the …

It has been known for more than 40 years that individual neurons can produce more than
one neurotransmitter and that neuropeptides often are colocalized with small molecule …

The brain clock that drives circadian rhythms of locomotor activity relies on a multi-oscillator
neuronal network. In addition to synchronizing the clock with day-night cycles, light also …