5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future
S Vodenkova, T Buchler, K Cervena… - Pharmacology & …, 2020 - Elsevier
Fluorouracil (5-FU) is an essential component of systemic chemotherapy for colorectal
cancer (CRC) in the palliative and adjuvant settings. Over the past four decades, several …
cancer (CRC) in the palliative and adjuvant settings. Over the past four decades, several …
[HTML][HTML] Drug resistance and new therapies in colorectal cancer
K Van der Jeught, HC Xu, YJ Li, XB Lu… - World journal of …, 2018 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is often diagnosed at an advanced stage when tumor cell
dissemination has taken place. Chemo-and targeted therapies provide only a limited …
dissemination has taken place. Chemo-and targeted therapies provide only a limited …
[HTML][HTML] The role of alternative splicing in cancer: From oncogenesis to drug resistance
R Sciarrillo, A Wojtuszkiewicz, YG Assaraf… - Drug Resistance …, 2020 - Elsevier
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …
mRNA are removed and protein-coding segments are assembled in diverse combinations …
Pharmacologic resistance in colorectal cancer: a review
WA Hammond, A Swaika… - Therapeutic advances in …, 2016 - journals.sagepub.com
Colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in
both men and women worldwide. This is in spite of widespread, effective measures of …
both men and women worldwide. This is in spite of widespread, effective measures of …
[HTML][HTML] Synonymous mutations frequently act as driver mutations in human cancers
Synonymous mutations change the sequence of a gene without directly altering the
sequence of the encoded protein. Here, we present evidence that these" silent" mutations …
sequence of the encoded protein. Here, we present evidence that these" silent" mutations …
The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains
An expanded GGGGCC hexanucleotide in C9ORF72 (C9) is the most frequent known cause
of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It has been …
of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It has been …
Alternative splicing and cell survival: from tissue homeostasis to disease
MP Paronetto, I Passacantilli, C Sette - Cell Death & Differentiation, 2016 - nature.com
Most human genes encode multiple mRNA variants and protein products through alternative
splicing of exons and introns during pre-mRNA processing. In this way, alternative splicing …
splicing of exons and introns during pre-mRNA processing. In this way, alternative splicing …
[HTML][HTML] Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated …
I Genovese, A Ilari, YG Assaraf, F Fazi… - Drug Resistance Updates, 2017 - Elsevier
The development of drug resistance continues to be a dominant hindrance toward curative
cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and …
cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and …
MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells
S Alvarez-Díaz, N Valle… - Human molecular …, 2012 - academic.oup.com
Vitamin D deficiency is associated with the high risk of colon cancer and a variety of other
diseases. The active vitamin D metabolite 1α, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) …
diseases. The active vitamin D metabolite 1α, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) …