Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Coronaviruses (CoVs) are important human pathogens for which no specific treatment is
available. Here, we provide evidence that pharmacological reprogramming of ER stress …

Proteotoxic stress causes profound endoplasmic reticulum (ER) membrane remodeling into
a perinuclear quality control compartment (ERQC) for the degradation of misfolded proteins …

Primary liver cancer is the third leading cause of cancer death in the world, and the lack of
effective treatments is the main reason for the high mortality. Corosolic acid (CA) has been …

To promote the biochemical reactions of life, cells can compartmentalize molecular
interaction partners together within separated non–membrane-bound regions. It is unknown …

Abstract Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics,
yet mechanistic links have remained elusive. T1D results from autoimmune destruction of …

Protein aggregation is a common feature of the protein misfolding or conformational
diseases, among them most of the neurodegenerative diseases. These disorders are a …

HERPUD1 is an important early marker of endoplasmic reticulum stress (ERS) and is
involved in the ubiquitination and degradation of several unfolded proteins. However, its role …

Maintaining functional protein homeostasis (proteostasis) is a constant challenge in the face
of limited protein-folding capacity, environmental threats, and aging. Cells have developed …