Over the past 15 years there has been an explosion of research on the dynamical properties
of proteins, largely driven by the emergence of a handful of techniques that are sensitive to …

An increasing number of examples in the literature suggest that the in vivo duration of drug
action not only depends on macroscopic pharmacokinetic properties like plasma half‐life …

The construction of bioactive peptides using β-amino acid-containing sequence patterns is a
very promising strategy to obtain analogues that exhibit properties of high interest for …

G protein-coupled receptors (GPCRs) are seven transmembrane helical bundle proteins
(Figure 1) found on the surface of all cells. 1-3 They mediate cellular responses to a diverse …

The lipid monolayer model membrane is useful for studying the parameters responsible for
protein and peptide membrane binding. Different approaches have been used to determine …

Mersacidin belongs to the type B lantibiotics (lanthionine-containing antibiotics) that contain
post-translationally modified amino acids and cyclic ring structures. It targets the cell wall …

Single molecule analysis of proteins in an aqueous environment without modification (eg,
labels or tethers) elucidates their biophysics and interactions relevant to drug discovery. By …

Neuropeptide Y (NPY) has been found to adopt two stable conformations in vivo:(1) a
monomeric form called the PP-fold in which a polyproline tail is folded onto an α-helix via a β …

Despite recent breakthroughs in the structural characterization of G‐protein‐coupled
receptors (GPCRs), there is only sparse data on how GPCRs recognize larger peptide …

Many biological functions of peptides are mediated through G protein-coupled receptors
(GPCRs). Upon ligand binding, GPCRs undergo conformational changes that facilitate the …