A high number of cancer patients around the world rely on gemcitabine (GEM) for
chemotherapy. During local metastasis of cancers, surgery is beneficial for therapy, but …

Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …

Pancreatic cancer (PC) is a serious gastrointestinal tract disease for which the 5-year
survival rate is less than 10%, even in developed countries such as the USA. The genomic …

Pancreatic cancer is characterized by hidden onset, high malignancy, and early metastasis.
Although a few cases meet the surgical indications, chemotherapy remains the primary …

Triple-negative breast cancer (TNBC), a highly aggressive and heterogeneous subtype of
breast cancer, lacks effective treatment options. Sophora flavescens Aiton, a Chinese …

Background: As lung cancer is the leading cause of cancer death worldwide, the
development of new medicines is a crucial endeavor. Naringenin, a flavanone derivative …

Increasing leptin resistance and methylglyoxal (MG) levels have been observed in patients
with obesity, which is characterized by an imbalance in energy metabolism and abnormal fat …

Pancreatic cancer (PC) has a high degree of malignancy and poor prognosis, and countless
patients have distant metastasis when diagnosed. Gemcitabine (GEM) chemotherapy is one …

Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent form, accounting for more
than 90% of all pancreatic malignancies. In a previous study, we found that hypoxia and …

High mobility group protein 1 (HMGB1) plays a complex role in tumor biology. When
released into the extracellular space, it binds to the receptor for advanced glycation end …