Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Boron-containing molecules have been extensively used for the purposes of chemical
sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it …

Binuclear metallohydrolases are a structurally diverse group of enzymes that use binuclear
metal ion centers to catalyze the hydrolysis of amides and esters of carboxylic and …

Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

Anthropogenic activity has increased human exposure to metals and resulted in metal
induced toxicity. Essential trace elements like cobalt (Co), nickel (Ni), and manganese (Mn) …

Boron has become crucial weapon in anticancer research due to significant intervention in
the cell proliferation. Being an excellent bio-isosteric replacement for carbon, it has …

Abstract Arginase (EC 3.5. 3.1) is the bimanganese enzyme that converts L‐arginine into
ornithine and urea. This enzyme was discovered more than a century ago and early α …

The β-lactams remain the most important antibacterials, but their use is increasingly
compromised by resistance, importantly by β-lactamases. Although β-lactam and non-β …

Mammalian arginases I and II require an intact binuclear manganese cluster for the
hydrolysis of l-arginine to generate l-ornithine and urea. Although arginase isozymes differ …

Cancer is the second leading cause of death globally. Chemotherapy and radiation therapy
and other medications are employed to treat various types of cancer. However, each …