HDL is a complex macromolecular cluster of various components, such as apolipoproteins,
enzymes and lipids. Quality evidence from clinical and epidemiological studies led to the …

Cholesterol is required for maintenance of plasma membrane fluidity and integrity and for
many cellular functions. Cellular cholesterol can be obtained from lipoproteins in a selective …

Clinically, combined therapy of cisplatin (CDDP) and metformin is an effective treatment for
non-small cell lung cancer (NSCLC). The success is attributed to synergistic effects between …

Rare diseases, especially monogenic diseases, which usually affect a single target protein,
have attracted growing interest in drug research by encouraging pharmaceutical companies …

Propranolol is a widely used beta blocker that consists of a racemic mixture of R and S
stereoisomers. Only the S stereoisomer has significant activity against the beta-adrenergic …

Porphobilinogen deaminase (PBGD) haploinsufficiency (acute intermittent porphyria, AIP) is
characterized by neurovisceral attacks associated with high production, accumulation and …

The liver is a vital metabolic and detoxifying organ and suffers diverse endogenous or
exogenous damage. Hepatocyte mitochondria experience various structural and functional …

Emerging evidence strongly supports that changes in the HDL metabolic pathway, which
result in changes in HDL proteome and function, appear to have a causative impact on a …

Tissue damage in diabetes is at least partly due to elevated reactive oxygen species
production by the mitochondrial respiratory chain during hyperglycemia. Sustained …

Acute porphyria attacks are associated with the strong up-regulation of hepatic heme
synthesis and over-production of neurotoxic heme precursors. First-line therapy is based on …