A review and database of snake venom proteomes

T Tasoulis, GK Isbister - Toxins, 2017 - mdpi.com
Advances in the last decade combining transcriptomics with established proteomics
methods have made possible rapid identification and quantification of protein families in …

[HTML][HTML] Snake venom metalloproteinases (SVMPs): a structure-function update

OT Olaoba, PK Dos Santos, HS Selistre-de-Araujo… - Toxicon: X, 2020 - Elsevier
Snake venom metalloproteinases (SVMPs) represent a diverse group of multi-domain
proteins with several biological activities such as the ability to induce hemorrhage …

Convergent evolution of pain-inducing defensive venom components in spitting cobras

TD Kazandjian, D Petras, SD Robinson, J van Thiel… - Science, 2021 - science.org
Convergent evolution provides insights into the selective drivers underlying evolutionary
change. Snake venoms, with a direct genetic basis and clearly defined functional …

Venomics: integrative venom proteomics and beyond

JJ Calvete - Biochemical Journal, 2017 - portlandpress.com
Venoms are integrated phenotypes that evolved independently in, and are used for
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …

In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom

L Ledsgaard, AH Laustsen, U Pus, J Wade, P Villar… - MAbs, 2022 - Taylor & Francis
The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia
due to its toxicity, which is predominantly derived from long-chain α-neurotoxins. The only …

From fangs to pharmacology: the future of snakebite envenoming therapy

AH Laustsen, M Engmark, C Milbo… - Current …, 2016 - ingentaconnect.com
The snake is the symbol of medicine due to its association with Asclepius, the Greek God of
medicine, and so with good reasons. More than 725 species of venomous snakes have …

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

AH Laustsen, A Karatt-Vellatt, EW Masters… - Nature …, 2018 - nature.com
The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the
African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins …

Current technology for the industrial manufacture of snake antivenoms

G León, M Vargas, Á Segura, M Herrera, M Villalta… - Toxicon, 2018 - Elsevier
Snake antivenoms are formulations of animal immunoglobulins used in the treatment of
snakebite envenomation. The general scheme for producing snake antivenoms has …

Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …

Venom proteomics and antivenom neutralization for the Chinese eastern Russell's viper, Daboia siamensis from Guangxi and Taiwan

KY Tan, NH Tan, CH Tan - Scientific reports, 2018 - nature.com
The eastern Russell's viper (Daboia siamensis) causes primarily hemotoxic envenomation.
Applying shotgun proteomic approach, the present study unveiled the protein complexity …