Oral drug delivery of proteins is limited by the degradative environment of the
gastrointestinal tract and poor absorption, requiring parenteral administration of these drugs …

Virus-like particles (VLPs) have natural structural antigens similar to those found in viruses,
making them valuable in vaccine immunization. Furthermore, VLPs have demonstrated …

Introduction Rapid advances in bioengineering enable the use of complex proteins as
therapeutic agents to treat diseases. Compared with conventional small molecule drugs …

Biopharmaceuticals, including proteins and peptides, have revolutionized the treatment of a
wide range of diseases, from diabetes and cardiovascular disorders to virus infections and …

Synthetic micromotor has gained substantial attention in biomedicine and environmental
remediation. Metal-based degradable micromotor composed of magnesium (Mg), zinc (Zn) …

Targeting the release of drugs in specific sites of the upper GI tract would meet local
therapeutic goals, improve the bioavailability of specific drugs and help overcoming …

Proteins and peptides often require frequent needle-based administrations. Here, we report
a non-parenteral delivery method for proteins through physical mixing with protamine, an …

Highlights•Enzymes in the gastrointestinal tract limit the therapeutic oral delivery of
macromolecules.•Physical ingestible devices are being developed to improve …

Injectable scaffolds are a promising strategy to restore and regenerate damaged and
diseased tissues. They require minimally invasive procedure and allow the formation of an …

Oral dosage forms are the preferred solution for systemic treatment and prevention of
disease conditions. However, traditional dosage forms face challenges regarding treatment …