Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

NMR spectroscopy for metabolomics research

AH Emwas, R Roy, RT McKay, L Tenori, E Saccenti… - Metabolites, 2019 - mdpi.com
Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …

Parahydrogen‐based hyperpolarization for biomedicine

JB Hövener, AN Pravdivtsev, B Kidd… - Angewandte Chemie …, 2018 - Wiley Online Library
Magnetic resonance (MR) is one of the most versatile and useful physical effects used for
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …

Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques

KV Kovtunov, EV Pokochueva… - Chemistry–An Asian …, 2018 - Wiley Online Library
The intensity of NMR signals can be enhanced by several orders of magnitude by using
various techniques for the hyperpolarization of different molecules. Such approaches can …

Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization

T Theis, ML Truong, AM Coffey… - Journal of the …, 2015 - ACS Publications
Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to
nitrogen-15 in pyridine and nicotinamide (vitamin B3 amide) by conducting “signal …

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research

J Kurhanewicz, DB Vigneron, K Brindle… - Neoplasia, 2011 - Elsevier
A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …

The theory and practice of hyperpolarization in magnetic resonance using parahydrogen

RA Green, RW Adams, SB Duckett, RE Mewis… - Progress in nuclear …, 2012 - Elsevier
NMR spectroscopy is arguably the most powerful and versatile analytical spectroscopic
method available to analyze nuclides which possess a magnetic dipole moment and …

Iridium N-Heterocyclic Carbene Complexes as Efficient Catalysts for Magnetization Transfer from para-Hydrogen

MJ Cowley, RW Adams, KD Atkinson… - Journal of the …, 2011 - ACS Publications
While the characterization of materials by NMR is hugely important in the physical and
biological sciences, it also plays a vital role in medical imaging. This success is all the more …

15N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH

ML Truong, T Theis, AM Coffey… - The journal of …, 2015 - ACS Publications
NMR signal amplification by reversible exchange (SABRE) is a NMR hyperpolarization
technique that enables nuclear spin polarization enhancement of molecules via concurrent …

Alkyne Semihydrogenation with a Well-Defined Nonclassical Co–H2 Catalyst: AH2 Spin on Isomerization and E-Selectivity

K Tokmic, AR Fout - Journal of the American Chemical Society, 2016 - ACS Publications
The reactivity of a CoI–H2 complex was extended toward the semihydrogenation of internal
alkynes. Under ambient temperatures and moderate pressures of H2, a broad scope of …