[HTML][HTML] A review on the screening methods for the discovery of natural antimicrobial peptides

B Yang, H Yang, J Liang, J Chen, C Wang… - Journal of …, 2024 - Elsevier
Natural antimicrobial peptides (AMPs) are promising candidates for the development of a
new generation of antimicrobials to combat antibiotic-resistant pathogens. They have found …

Antimicrobial peptides: Structure, mechanism, and modification

N Chen, C Jiang - European Journal of Medicinal Chemistry, 2023 - Elsevier
From the 1940s to the 1960s, the discovery of antibiotics held substantial promise for the
treatment of bacterial infection, and it was also widely used in food, agriculture, and other …

[HTML][HTML] Antimicrobial peptides: Opportunities and challenges in overcoming resistance

C Bucataru, C Ciobanasu - Microbiological Research, 2024 - Elsevier
Antibiotic resistance represents a global health threat, challenging the efficacy of traditional
antimicrobial agents and necessitating innovative approaches to combat infectious …

Unraveling the role of antimicrobial peptides in insects

S Stączek, M Cytryńska… - International journal of …, 2023 - mdpi.com
Antimicrobial peptides (AMPs) are short, mainly positively charged, amphipathic molecules.
AMPs are important effectors of the immune response in insects with a broad spectrum of …

Recent progress in the discovery and design of antimicrobial peptides using traditional machine learning and deep learning

J Yan, J Cai, B Zhang, Y Wang, DF Wong, SWI Siu - Antibiotics, 2022 - mdpi.com
Antimicrobial resistance has become a critical global health problem due to the abuse of
conventional antibiotics and the rise of multi-drug-resistant microbes. Antimicrobial peptides …

CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications

S Feng, S Park, YK Choi, W Im - Journal of chemical theory and …, 2023 - ACS Publications
Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …

[HTML][HTML] Design strategies for positively charged endolysins: insights into Artilysin development

JV Carratalá, A Arís, E Garcia-Fruitós… - Biotechnology …, 2023 - Elsevier
Endolysins are bacteriophage-encoded enzymes that can specifically degrade the
peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development …

Accelerating the discovery and design of antimicrobial peptides with artificial intelligence

MC Aguilera-Puga, NL Cancelarich, MM Marani… - … drug discovery and …, 2023 - Springer
Peptides modulate many processes of human physiology targeting ion channels, protein
receptors, or enzymes. They represent valuable starting points for the development of new …

[HTML][HTML] Peptaibiotics: harnessing the potential of microbial secondary metabolites for mitigation of plant pathogens

L Pereira-Dias, PR Oliveira-Pinto, JO Fernandes… - Biotechnology …, 2023 - Elsevier
Agricultural systems are in need of low-cost, safe antibiotics to protect crops from pests and
diseases. Peptaibiotics, a family of linear, membrane-active, amphipathic polypeptides, have …

Algorithms for de-novo sequencing of peptides by tandem mass spectrometry: a review

CCA Ng, Y Zhou, ZP Yao - Analytica Chimica Acta, 2023 - Elsevier
Peptide sequencing is of great significance to fundamental and applied research in the
fields such as chemical, biological, medicinal and pharmaceutical sciences. With the rapid …