Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Biological studies of bipolar disorder initially focused on the mechanism of action for
antidepressants and antipsychotic drugs, and the roles of monoamines (eg, serotonin …

Bipolar disorder (BD) is a heritable neuropsychiatric disorder with largely unknown
pathogenesis. Given their prominent role in brain function and disease, we hypothesized …

Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%,
the effective treatment, and prevention of bipolar disorder represents an area of significant …

Specialized RNA-seq methods are required to identify the 5′ ends of transcripts, which are
critical for studies of gene regulation, but these methods have not been systematically …

AnkyrinG, encoded by the ANK3 gene, is involved in neuronal development and signaling. It
has previously been implicated in bipolar disorder and schizophrenia by association …

Importance The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully
understood. Objective To explore the genetic basis of BD in the Han Chinese population …

Homer1 is a synaptic scaffold protein that regulates glutamatergic synapses and spine
morphogenesis. HOMER1 knockout (KO) mice show behavioral abnormalities related to …

All psychiatric disorders have suffered from a dearth of truly novel pharmacological
interventions. In bipolar disorder, lithium remains a mainstay of treatment, six decades since …

Cortical circuit activity is shaped by the parvalbumin (PV) and somatostatin (SST)
interneurons that inhibit principal excitatory (EXC) neurons and the vasoactive intestinal …