The application of single-cell RNA sequencing platforms has generated notable insights into
the heterogeneity underlying pancreatic ductal adenocarcinoma (PDAC), encompassing …

Tissue-resident macrophages (TRMs) are long-lived cells that maintain locally and can be
phenotypically distinct from monocyte-derived macrophages. Whether TRMs and monocyte …

Presentation of tumor antigens is a critical step in producing a robust antitumor immune
response. Classically tumor antigens are thought to be presented to both CD8 and CD4 T …

Purpose: FOLFIRINOX has demonstrated promising results for patients with pancreatic
ductal adenocarcinoma (PDAC). Chemotherapy-induced immunogenic cell death can prime …

Although cancer-associated fibroblast (CAF) heterogeneity is well-established, the impact of
chemotherapy on CAF populations remains poorly understood. Here we address this …

Single-cell RNA sequencing (scRNAseq) has been used to assess the intra-tumor
heterogeneity and microenvironment of pancreatic ductal adenocarcinoma (PDAC) …

Bulk analyses of pancreatic ductal adenocarcinoma (PDAC) samples are complicated by the
tumor microenvironment (TME), ie signals from fibroblasts, endocrine, exocrine, and immune …

Simple Summary Reshaped pancreatic tumor microenvironment by chemotherapy,
ultimately preventing or promoting tumor progression, is presented by the alteration of …

A chronic inability to maintain blood glucose homeostasis leads to diabetes, which can
damage multiple organs. The pancreatic islets regulate blood glucose levels through the …

Tissue-resident macrophages (TRMs) are long-lived cells that maintain locally and can be
phenotypically distinct from monocyte-derived macrophages (MDMs). However, whether …