Reproducible quantification of biomarker expression

J Christiansen, R Pinard, M Gustavson… - US Patent …, 2016 - Google Patents
A method is described for the reproducible quantification of biomarker expression, including
biomarker expression in a tissue sample. Methods and systems are described whereby …

Methods of generating trophectoderm and neurectoderm from human embryonic stem cells

PJ Sammak, R Mangoubi, TM Erb, S Mucko… - US Patent …, 2017 - Google Patents
2011-03-02 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Automatic exposure time selection for imaging tissue

J Christiansen, DM Reilly, B Bourke-martin… - US Patent …, 2011 - Google Patents
BACKGROUND Platforms for the analysis of tissue-based quantitative pro tein biomarker
assay studies and clinical diagnostics tend to have variable results due to operator …

Methods and system for validating sample images for quantitative immunoassays

R Pinard, GR Tedeschi, C Williams, D Wang - US Patent 8,160,348, 2012 - Google Patents
US8160348B2 - Methods and system for validating sample images for quantitative
immunoassays - Google Patents US8160348B2 - Methods and system for validating …

Method and system for standardizing microscope instruments

J Christiansen, R Pinard, MP Zerkowski… - US Patent …, 2011 - Google Patents
US7907271B2 - Method and system for standardizing microscope instruments - Google
Patents US7907271B2 - Method and system for standardizing microscope instruments …

Methods and compositions for predicting death from cancer and prostate cancer survival using gene expression signatures

GV Glinskii - US Patent 8,349,555, 2013 - Google Patents
cancers include a small number of cells in tumors with significant biological resemblance to
stem cells, which are unspecialized, precursor cells with the ability to quickly divide and …

Methods and system for validating sample images for quantitative immunoassays

R Pinard, GR Tedeschi, C Williams, D Wang - US Patent 8,417,015, 2013 - Google Patents
(57) ABSTRACT A method and system for automatically evaluating quality of a slide-
mounted tissue sample includes receiving a digital image of a magni? ed portion of the slide …

Compartment segregation by pixel characterization using image data clustering

JH Christiansen, R Pinard, M Gustavson… - US Patent …, 2012 - Google Patents
5,126,577 A 6, 1992 Trent 5.244. 787 A 9, 1993 K. 1 6,780,377 B2 8/2004 Hall et al. 4 ey et
al. 6,800,249 B2 10/2004 De la Torre-Bueno 5,254,845. A 10/1993 Burgess et al. 6,816,625 …

Method and system for determining an optimal dilution of a reagent

R Pinard, GR Tedeschi, M Gustavson - US Patent 8,121,365, 2012 - Google Patents
A system and method for automatically and quantitatively determining the optimal dilution of
a reagent is provided. In one embodiment of the claimed method, a plurality of dilution sets …

High throughput, optical method and system for determining the effect of a test substance on non-contiguous living cells

JD Trumbull, GA Gintant, S Kantor, JY Pan… - US Patent …, 2015 - Google Patents
(57) ABSTRACT A rapid and efficient method and apparatus for detecting
electrophysiologic, proarrhythmic, contractile, and other effects of Substances Such as …