Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Genome sequencing and gene expression analyses of prostate tumours have highlighted
the potential importance of genetic and epigenetic changes observed in WNT signalling …

The Wnts are secreted cysteine-rich glycoproteins that have important roles in the
developing embryo as well as in tissue homeostasis in adults. Dysregulation of Wnt …

Runx2, a bone-specific transcriptional regulator, is abnormally expressed in highly
metastatic prostate cancer cells. Here, we identified the functional activities of Runx2 in …

The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic
stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate …

In prostate cancer, androgen blockade strategies are commonly used to treat osteoblastic
bone metastases. However, responses to these therapies are typically brief, and the …

BACKGROUND Prostate cancer (PCa) frequently metastasizes to the bone and induces
osteoblastic lesions. We previously demonstrated through over‐expression of the Wnt …

Metastatic or locally advanced prostate cancer (PCa) is typically treated with androgen
deprivation therapy (ADT). Initially, PCa responds to the treatment and regresses. However …

BACKGROUND: Dickkopf-1 (DKK-1), an inhibitor of the Wnt pathway, has recently emerged
as an important player in several critical aspects of bone biology. METHODS: We performed …

Prostate cancer (PCa) frequently metastasizes to the bone, generally inducing osteoblastic
alterations that increase bone brittleness. Although there is growing interest in the …