Antimicrobial and chemotherapy resistance are escalating medical problem of paramount
importance. Yet, research for novel antimicrobial and anticancer agents remains lagging …

Background SIMR1281 is a potent anticancer lead candidate with multi-target activity
against several proteins; however, its mechanism of action at the molecular level is not fully …

Acanthamoeba spp. are pathogens that cause Acanthamoeba keratitis (AK), a serious
cornea inflammation that can lead to gradual loss of vision, permanent blindness, and …

Background Acanthamoeba spp. is the causative agent of Acanthamoeba keratitis and
granulomatous amoebic encephalitis. Strathclyde minor groove binders (S-MGBs) are a …

Acanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis
and granulomatous amoebic encephalitis in humans. Treatment remains limited and …

Spectroscopic, biochemical, and computational modelling studies have been used to assess
the binding capability of a set of minor groove binding (MGB) ligands against the self …

Breast cancer poses a significant health risk worldwide. However, the effectiveness of
current chemotherapy is limited due to increasing drug resistance and side effects, making it …

DNA minor groove binders exhibit a high degree of sequence specificity and have a variety
of biological actions including antiviral, anticancer, antibacterial, and anti-protozoal …