Cyclic dipeptides: The biological and structural landscape with special focus on the anti-cancer proline-based scaffold

J Bojarska, A Mieczkowski, ZM Ziora, M Skwarczynski… - Biomolecules, 2021 - mdpi.com
Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of
peptides widespread in nature, are unsurpassed in their structural and bio-functional …

Stability of protein pharmaceuticals: Recent advances

MC Manning, RE Holcomb, RW Payne… - Pharmaceutical …, 2024 - Springer
There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …

Recent advancement in inhaled nano-drug delivery for pulmonary, nasal, and nose-to-brain diseases

Q Fu, Y Liu, C Peng, TA Muluh, U Anayyat… - Current Drug …, 2025 - benthamdirect.com
Pulmonary, nasal, and nose-to-brain diseases involve clinical approaches, such as
bronchodilators, inhaled steroids, oxygen therapy, antibiotics, antihistamines, nasal steroids …

Influence of N Terminus Amino Acid on Peptide Cleavage in Solution through Diketopiperazine Formation

Z Zhang, DA Hales, DE Clemmer - Journal of the American …, 2022 - ACS Publications
Diketopiperazine (DKP) formation is an important degradation pathway for peptides and
proteins. It can occur during synthesis and storage in either solution or the solid state. The …