Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Innate immune cells play essential roles in modulating both immune defense and
inflammation by expressing a diverse array of cytokines and inflammatory mediators …

The histone variant macroH2A is generally linked to transcriptionally inactive chromatin, but
how macroH2A regulates chromatin structure and functions in the transcriptional process …

Childhood neuroblastoma with MYCN amplification is classified as high risk and often
relapses after intensive treatments. Immune checkpoint blockade therapy against the PD …

High levels of H2A. Z promote melanoma cell proliferation and correlate with poor
prognosis. However, the role of the two distinct H2A. Z histone chaperone complexes …

Cancer has been described as the wound that does not heal, in large part due to fibroblast
involvement. Activation of cancer-associated fibroblasts (CAFs) contributes to critical …

MacroH2A has been linked to transcriptional silencing, cell identity, and is a hallmark of the
inactive X chromosome (Xi). However, it remains unclear whether macroH2A plays a role in …

Cancer-associated fibroblasts (CAFs) exhibit notable versatility, plasticity, and robustness,
actively participating in cancer progression through intricate interactions within the tumor …

High levels of H2A. Z promote melanoma cell proliferation and correlate with poor
prognosis. However, the role of the two distinct H2A. Z histone chaperone complexes …

Histone variants contribute to epigenetic regulation in development and disease but require
the chaperone machinery for correct deposition. In this issue of Molecular Cell, Ji et al. 1 …