Breast cancer progression is highly dependent on the heterotypic interaction between tumor
cells and stromal cells of the tumor microenvironment. Cancer-associated adipocytes …

Adipose tissues collectively as an endocrine organ and energy storage are crucial for
systemic metabolic homeostasis. The major cell type in the adipose tissue, the adipocytes or …

Objective/methods DNA methylation plays an important role in obesity and related metabolic
complications. We examined genome-wide DNA promoter methylation along with mRNA …

Liposarcomas (LPSs) are the most common soft-tissue cancer. Because of the lack of animal
models, the cellular origin and molecular regulation of LPS remain unclear. Here, we report …

Lipodystrophy is a disorder featuring loss of normal adipose tissue depots due to impaired
production of normal adipocytes. It leads to a gain of fat deposition in ectopic tissues such as …

Epidemiological evidence showed that patients suffering from obesity and T2DM are
significantly at higher risk for chronic low-grade inflammation, oxidative stress, nonalcoholic …

Adipose tissues, composed with mature adipocytes and preadipocytic stromal/stem cells,
play crucial roles in whole body energy metabolism and regenerative medicine. Mature …

Curcumin is a well‑known phenolic substance and has many pharmacological effects
associated with metabolism. However, the exact molecular mechanisms underlying this …

Insulin resistance is associated with increased incidence and enhanced progression of
cancers. However, little is known about strategies that can effectively ameliorate insulin …

The importance of macrophages in adipose tissue (AT) homeostasis and inflammation is
well established. However, the potential cues that regulate their function remain …