Lung cancer mutation profile of EGFR, ALK, and KRAS: Meta-analysis and comparison of never and ever smokers

AM Chapman, KY Sun, P Ruestow, DM Cowan… - Lung cancer, 2016 - Elsevier
Lung cancer is the leading cause of cancer-related mortality. While the majority of lung
cancers are associated with tobacco smoke, approximately 10–15% of US lung cancers …

EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations

E Thunnissen, L Bubendorf, M Dietel, G Elmberger… - Virchows Archiv, 2012 - Springer
In non-small cell lung cancer, epidermal growth factor receptor gene mutations and
anaplastic lymphoma kinase (ALK) gene rearrangements have a major impact upon the …

[HTML][HTML] Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American …

NI Lindeman, PT Cagle, MB Beasley, DA Chitale… - Journal of Thoracic …, 2013 - Elsevier
Objective To establish evidence-based recommendations for the molecular analysis of lung
cancers that are that are required to guide EGFR-and ALK-directed therapies, addressing …

Associations Between Mutations and Histologic Patterns of Mucin in Lung Adenocarcinoma: Invasive Mucinous Pattern and Extracellular Mucin Are Associated With …

K Kadota, YC Yeh, SP D'Angelo… - The American journal …, 2014 - journals.lww.com
Multiple reports indicate that epidermal growth factor receptor (EGFR) mutations are
associated with lepidic-pattern lung adenocarcinoma and that KRAS mutations are …

Prevalence and clinical outcomes for patients with ALK-positive resected stage I to III adenocarcinoma: results from the European Thoracic Oncology Platform …

FH Blackhall, S Peters, L Bubendorf, U Dafni… - Journal of clinical …, 2014 - ascopubs.org
Purpose The prevalence of anaplastic lymphoma kinase (ALK) gene fusion (ALK positivity)
in early-stage non–small-cell lung cancer (NSCLC) varies by population examined and …

[HTML][HTML] The cribriform pattern identifies a subset of acinar predominant tumors with poor prognosis in patients with stage I lung adenocarcinoma: a conceptual …

K Kadota, YC Yeh, CS Sima, VW Rusch, AL Moreira… - Modern Pathology, 2014 - Elsevier
Abstract The 2011 International Association for the Study of Lung Cancer (IASLC)/American
Thoracic Society (ATS)/European Respiratory Society (ERS) lung adenocarcinoma …

[HTML][HTML] ALK-gene rearrangement: a comparative analysis on circulating tumour cells and tumour tissue from patients with lung adenocarcinoma

M Ilie, E Long, C Butori, V Hofman, C Coelle, V Mauro… - Annals of oncology, 2012 - Elsevier
Background A subgroup of anaplastic lymphoma kinase (ALK)-rearranged lung tumours can
respond to ALK inhibitors. Until now, the ALK status in circulating tumour cells (CTCs) …

Limited resection is associated with a higher risk of locoregional recurrence than lobectomy in stage I lung adenocarcinoma with tumor spread through air spaces

K Kadota, Y Kushida, S Kagawa… - The American journal …, 2019 - journals.lww.com
A growing number of independent studies have validated spread through air spaces (STAS)
to be a predictor of worse prognosis in lung adenocarcinoma. To investigate the prognostic …

Brain metastases in patients with ALK+ non-small cell lung cancer: clinical symptoms, treatment patterns and economic burden

A Guérin, M Sasane, J Zhang, KW Culver… - Journal of medical …, 2015 - Taylor & Francis
Objective: Brain metastases (BM) are highly prevalent among anaplastic lymphoma kinase
positive (ALK+) non-small cell lung cancer (NSCLC) patients; yet little is known about their …

A review of biomarkers and their clinical impact in resected early-stage non-small-cell lung cancer

W Cao, Q Tang, J Zeng, X Jin, L Zu, S Xu - Cancers, 2023 - mdpi.com
Simple Summary Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of
all lung cancers, and the postoperative survival of early-stage NSCLC patients remains …