Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …

Viral infection is controlled by host innate immune cells that express specialized receptors
for viral components. Engagement of these pattern recognition receptors triggers a series of …

Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is
indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …

TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …

Abstract Gasdermin-D (GSDMD), the executioner of pyroptotic cell death when it is cleaved
by inflammatory caspases, plays a crucial role in host defense and the response to danger …

Influenza A virus (IAV) has evolved various strategies to counteract the innate immune
response using different viral proteins. However, the mechanism is not fully elucidated. In …

As an important post-translational modification, ubiquitination mediates∼ 80% of protein
degradation in eukaryotes. The degree of protein ubiquitination is tightly determined by the …

MAVS and MITA are essential adaptor proteins mediating innate antiviral immune
responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays …