Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila

NJ Himmel, A Sakurai, AA Patel, S Bhattacharjee… - Elife, 2023 - elifesciences.org
Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus-
relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between …

Drosophila menthol sensitivity and the Precambrian origins of transient receptor potential-dependent chemosensation

NJ Himmel, JM Letcher, A Sakurai… - … of the Royal …, 2019 - royalsocietypublishing.org
Transient receptor potential (TRP) cation channels are highly conserved, polymodal sensors
which respond to a wide variety of stimuli. Perhaps most notably, TRP channels serve critical …

Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior

R Das, S Bhattacharjee, JM Letcher, JM Harris… - …, 2021 - journals.biologists.com
Dendrite shape impacts functional connectivity and is mediated by organization and
dynamics of cytoskeletal fibers. Identifying the molecular factors that regulate dendritic …

Modality specific roles for metabotropic GABAergic signaling and calcium induced calcium release mechanisms in regulating cold nociception

AA Patel, A Sakurai, NJ Himmel… - Frontiers in molecular …, 2022 - frontiersin.org
Calcium (Ca2+) plays a pivotal role in modulating neuronal-mediated responses to modality-
specific sensory stimuli. Recent studies in Drosophila reveal class III (CIII) multidendritic …

Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization

SH Im, AA Patel, DN Cox… - Disease models & …, 2018 - journals.biologists.com
Diabetes-associated nociceptive hypersensitivity affects diabetic patients with hard-to-treat
chronic pain. Because multiple tissues are affected by systemic alterations in insulin …

Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development

JS Jaszczak, L DeVault, LY Jan, YN Jan - Elife, 2022 - elifesciences.org
Sensory neurons enable animals to detect environmental changes and avoid harm. An
intriguing open question concerns how the various attributes of sensory neurons arise in …

Sensing the cold: TRP channels in thermal nociception

NJ Himmel, DN Cox - Channels, 2017 - Taylor & Francis
Nociception, a mechanism evolutionarily conserved throughout Metazoa, mediates
protective behavioral responses to a range of stimuli, including noxious temperatures …

Chloride-dependent mechanisms of multimodal sensory discrimination and neuropathic sensitization in Drosophila

NJ Himmel, A Sakurai, JM Letcher, AA Patel… - bioRxiv, 2021 - biorxiv.org
Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus-
relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between …

[HTML][HTML] Neural substrates of cold nociception in Drosophila larva

AA Patel, A Cardona, DN Cox - bioRxiv, 2023 - ncbi.nlm.nih.gov
Metazoans detect and differentiate between innocuous (non-painful) and/or noxious
(harmful) environmental cues using primary sensory neurons, which serve as the first node …

Multiscale Systems Level Analyses of Cold Sensitive Somatosensory Neurons in Drosophila

AA Patel - 2022 - scholarworks.gsu.edu
Metazoans detect and differentiate between innocuous (non-painful) and/or noxious
(harmful) environmental cues using primary sensory neurons, which serve as the first node …