Transient receptor potential (TRP) cation channels are highly conserved, polymodal sensors which respond to a wide variety of stimuli. Perhaps most notably, TRP channels serve critical …
Dendrite shape impacts functional connectivity and is mediated by organization and dynamics of cytoskeletal fibers. Identifying the molecular factors that regulate dendritic …
Calcium (Ca2+) plays a pivotal role in modulating neuronal-mediated responses to modality- specific sensory stimuli. Recent studies in Drosophila reveal class III (CIII) multidendritic …
SH Im, AA Patel, DN Cox… - Disease models & …, 2018 - journals.biologists.com
Diabetes-associated nociceptive hypersensitivity affects diabetic patients with hard-to-treat chronic pain. Because multiple tissues are affected by systemic alterations in insulin …
Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in …
Nociception, a mechanism evolutionarily conserved throughout Metazoa, mediates protective behavioral responses to a range of stimuli, including noxious temperatures …
Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus- relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between …
Metazoans detect and differentiate between innocuous (non-painful) and/or noxious (harmful) environmental cues using primary sensory neurons, which serve as the first node …
Metazoans detect and differentiate between innocuous (non-painful) and/or noxious (harmful) environmental cues using primary sensory neurons, which serve as the first node …