Organophosphonic acids are unique as natural products in terms of stability and mimicry.
The C–P bond that defines these compounds resists hydrolytic cleavage, while the …

Since our initial report in 1976, the oxygen rebound mechanism has become the consensus
mechanistic feature for an expanding variety of enzymatic C–H functionalization reactions …

Abstract The 2-His-1-carboxylate facial triad is a widely used scaffold to bind the iron center
in mononuclear nonheme iron enzymes for activating dioxygen in a variety of oxidative …

Nonheme iron-dependent enzymatic reactions play crucial roles in building and modifying
bioactive organic molecules in all major classes of natural product pathways. While the …

Cyclopropane, epoxide, and aziridine groups are three-membered ring structural elements
found in a wide variety of natural products, some of which are depicted in Figure 1. 1 The …

In recent years there has been a surge in the development of methods for the synthesis of
organofluorine compounds. However, enzymatic methods for C–F bond formation have …

Aromatic polyketides, with their diverse structures and biological activities, have attracted
significant scientific interest. Aromatization reactions are typically performed by aromatases …

Over the past decade, several metalloenzymes have been characterized which catalyze
dioxygenase-type aliphatic carbon–carbon bond cleavage reactions. The substrates for …

The iron-dependent epoxidase HppE converts (S)-2-hydroxypropyl-1-phosphonate (S-HPP)
to the antibiotic fosfomycin [(1 R, 2 S)-epoxypropylphosphonate] in an unusual 1, 3 …

The assignment of biochemical functions to hypothetical proteins is challenged by functional
diversification within many protein structural superfamilies. This diversification, which is …