In recent years, much interest has been devoted to defining the role of the IGF system in the
nervous system. The ubiquitous IGFs, their cell membrane receptors, and their carrier …

There is abundant in vitro, animal and epidemiologic evidence to suggest that the Insulin-
Like Growth Factor (IGF) family is a multi-component network of molecules which is involved …

IGF-IR-mediated signaling promotes survival, anchorage-independent growth, and
oncogenic transformation, as well as tumor growth and metastasis formation in vivo. NVP …

Insulin-like growth factor-1 receptor (IGF-1R) is a receptor tyrosine kinase (RTK) and critical
activator of the phosphatidylinositol 3-kinase–AKT pathway. IGF-1R is required for …

Purpose: The insulin-like growth factor (IGF) signaling pathway is implicated in cellular
mitogenesis, angiogenesis, tumor cell survival, and tumorigenesis. Inhibition of this pathway …

The Abl family of nonreceptor tyrosine kinases consists of two related proteins, c-Abl and Abl-
related gene (Arg). Activated forms of the Abl kinases (BCR-Abl, Tel-Abl, and Tel-Arg) …

Cytochrome P 450 (CYP) epoxygenases convert arachidonic acid to four regioisomeric
epoxyeicosatrienoic acids (EET), which exert diverse biological activities in a variety of …

The TET2 DNA dioxygenase regulates gene expression by catalyzing demethylation of 5-
methylcytosine, thus epigenetically modulating the genome. TET2 does not contain a …

Interaction of insulin‐like growth factor receptor I (IGF‐IR) with its ligands has been reported
to induce cell proliferation, transformation and blockade of cell apoptotic functions. IGF‐IR is …

Mutant Abl kinases (such as BCR-Abl) drive the development of leukemia; however little is
known regarding whether Abl kinases contribute to the development or progression of solid …