OBJECTIVES: To perform a meta-analysis of the risk of relapse after discontinuation of anti-
tumor necrosis factor (anti-TNF) therapy in patients with Crohn's disease (CD) and ulcerative …

Background Safe and effective long‐term treatments that reduce the need for corticosteroids
are needed for Crohn's disease. Although purine antimetabolites are moderately effective for …

Background & Aims The IM-UNITI study and long-term extension (LTE) evaluated the long-
term efficacy, safety, and immunogenicity of subcutaneous ustekinumab maintenance …

Understanding neurotoxic mechanisms is a challenge of deciphering which genes and gene
products in the developing or mature nervous system are targeted for disruption by …

Background Although corticosteroids are effective for induction of remission of Crohn's
disease, many patients relapse when steroids are withdrawn or become steroid dependent …

Low-dose methotrexate (MTX) therapy is a well-recognized therapy for many inflammatory
conditions such as rheumatoid arthritis, psoriatic arthritis, and psoriasis. More than 20 years …

The authors review the clinical outcome in patients with Crohn's disease (CD) based on
studies describing the natural course of the disease. Population-based studies have …

Aliment Pharmacol Ther 2010; 32: 119–130 Summary Background Immunosuppression is a
risk factor for carcinogenesis. Thiopurines specifically contribute to this. As thiopurines are …

The emergence and spread of drug resistance in the malaria parasite Plasmodium
falciparum as well as multi-and extremely drug-resistant forms of Mycobacterium …

Background The therapeutic role of methotrexate (MTX) for management of inflammatory
bowel disease (IBD) remains unclear. Methods We systematically reviewed randomized …