Role of the extracellular matrix in regulating stem cell fate
FM Watt, WTS Huck - Nature reviews Molecular cell biology, 2013 - nature.com
The field of stem cells and regenerative medicine offers considerable promise as a means of
delivering new treatments for a wide range of diseases. In order to maximize the …
delivering new treatments for a wide range of diseases. In order to maximize the …
A tense situation: forcing tumour progression
DT Butcher, T Alliston, VM Weaver - Nature Reviews Cancer, 2009 - nature.com
Cells within tissues are continuously exposed to physical forces including hydrostatic
pressure, shear stress, and compression and tension forces. Cells dynamically adapt to …
pressure, shear stress, and compression and tension forces. Cells dynamically adapt to …
Preparation of hydrogel substrates with tunable mechanical properties
The modulus of elasticity of the extracellular matrix (ECM), often referred to in a biological
context as “stiffness,” naturally varies within the body, eg, hard bones and soft tissue …
context as “stiffness,” naturally varies within the body, eg, hard bones and soft tissue …
Mechanical integration of actin and adhesion dynamics in cell migration
ML Gardel, IC Schneider… - Annual review of cell …, 2010 - annualreviews.org
Directed cell migration is a physical process that requires dramatic changes in cell shape
and adhesion to the extracellular matrix. For efficient movement, these processes must be …
and adhesion to the extracellular matrix. For efficient movement, these processes must be …
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments
Contractile myocytes provide a test of the hypothesis that cells sense their mechanical as
well as molecular microenvironment, altering expression, organization, and/or morphology …
well as molecular microenvironment, altering expression, organization, and/or morphology …
Cellular traction stresses increase with increasing metastatic potential
CM Kraning-Rush, JP Califano, CA Reinhart-King - PloS one, 2012 - journals.plos.org
Cancer cells exist in a mechanically and chemically heterogeneous microenvironment
which undergoes dynamic changes throughout neoplastic progression. During metastasis …
which undergoes dynamic changes throughout neoplastic progression. During metastasis …
Soft biological materials and their impact on cell function
Most organs and biological tissues are soft viscoelastic materials with elastic moduli ranging
from on the order of 100 Pa for the brain to 100 000 Pa for soft cartilage. Biocompatible …
from on the order of 100 Pa for the brain to 100 000 Pa for soft cartilage. Biocompatible …
Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions
Multiple attributes of the three-dimensional (3D) extracellular matrix (ECM) have been
independently implicated as regulators of cell motility, including pore size, crosslink density …
independently implicated as regulators of cell motility, including pore size, crosslink density …
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance
MF Berry, AJ Engler, YJ Woo… - American Journal …, 2006 - journals.physiology.org
Cellular therapy for myocardial injury has improved ventricular function in both animal and
clinical studies, though the mechanism of benefit is unclear. This study was undertaken to …
clinical studies, though the mechanism of benefit is unclear. This study was undertaken to …
Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength
BC Isenberg, PA DiMilla, M Walker, S Kim, JY Wong - Biophysical journal, 2009 - cell.com
Mechanical compliance is emerging as an important environmental cue that can influence
certain cell behaviors, such as morphology and motility. Recent in vitro studies have shown …
certain cell behaviors, such as morphology and motility. Recent in vitro studies have shown …