Pharmacologic treatment of opioid use disorder: a review of pharmacotherapy, adjuncts, and toxicity

MS Toce, PR Chai, MM Burns, EW Boyer - Journal of Medical Toxicology, 2018 - Springer
Opioid use disorder continues to be a significant source of morbidity and mortality in the
USA and the world. Pharmacologic treatment with methadone and buprenorphine has been …

Clinical review: loperamide toxicity

PE Wu, DN Juurlink - Annals of emergency medicine, 2017 - Elsevier
Loperamide is a nonprescription opioid widely used for the treatment of diarrhea. Although it
is relatively safe at therapeutic doses, increasing reports describe its misuse and abuse at …

Trends in intentional abuse and misuse ingestions in school-aged children and adolescents reported to US poison centers from 2000-2020

AR Hughes, S Grusing, A Lin, RG Hendrickson… - Clinical …, 2023 - Taylor & Francis
Context Childhood and adolescent misuse and abuse exposures remain a serious public
health challenge in the United States. This study aimed to describe recent trends and …

Fatal poisonings associated with new psychoactive substances

R Kronstrand, D Guerrieri, S Vikingsson… - … , Clinical, Forensic and …, 2018 - Springer
This chapter describes how new psychoactive substances (NPS) have been involved in fatal
intoxications from 2010 and onwards. It summarizes the circumstances, antemortem …

Pharmacological aspects of over-the-counter opioid drugs misuse

Ł Sobczak, K Goryński - Molecules, 2020 - mdpi.com
Several over-the-counter (OTC) drugs are known to be misused. Among them are opioids
such as codeine, dihydrocodeine, and loperamide. This work elucidates their pharmacology …

Misuse of prescription and over-the-counter drugs to obtain illicit highs: How pharmacists can prevent abuse

S Chiappini, A Guirguis, J Corkery… - The Pharmaceutical …, 2020 - uhra.herts.ac.uk
There have been increasing reports of misuse of a range of prescription and over-the-
counter (OTC) drugs for recreational purposes. The use of psychoactive pharmaceuticals …

Is there such a thing as a'lope'dope? Analysis of loperamide-related European Medicines Agency (EMA) pharmacovigilance database reports

F Schifano, S Chiappini - PLoS One, 2018 - journals.plos.org
Background Among over-the-counter (OTC) drugs, loperamide has recently emerged for its
potential of misuse and cardiotoxicity issues. Hence, we aimed here at assessing the …

Balancing acts: The dual faces of fentanyl in medicine and public health

H Khatoon, SMM Faudzi - Legal Medicine, 2024 - Elsevier
Fentanyl is a potent synthetic opioid widely used in medicine for its effective analgesic
properties, particularly in surgical procedures and in the treatment of severe, chronic pain. In …

Uncovering the hidden burden of pharmaceutical poisoning in high-income and low-middle-income countries: A scoping review

C Cowans, A Love, B Tangiisuran, SA Jacob - Pharmacy, 2023 - mdpi.com
Pharmaceutical poisoning is a significant global public health concern, causing
approximately 190,000 deaths annually. This scoping review aims to comprehensively map …

Loperamide cardiotoxicity:“a brief review”

T Akel, S Bekheit - Annals of Noninvasive Electrocardiology, 2018 - Wiley Online Library
Loperamide is a popular antidiarrheal medication that has been used for many years. It is
currently gaining more attention among healthcare professionals due to its increasing …