Molecular mechanisms of health and disease are often represented as systems biology
diagrams, and the coverage of such representation constantly increases. These static …

Inference of gene regulatory networks has been an active area of research for around 20
years, leading to the development of sophisticated inference algorithms based on a variety …

Mechanistic computational models enable the study of regulatory mechanisms implicated in
various biological processes. These models provide a means to analyze the dynamics of the …

Acquiring a functional comprehension of the deregulation of cell signaling networks in
disease allows progress in the development of new therapies and drugs. Computational …

Post-translational modifications of proteins play an important role in the regulation of cellular
processes. The mass spectrometry analysis of proteome modifications offers huge potential …

Cancer cells depend on multiple driver alterations whose oncogenic effects can be
suppressed by drug combinations. Here, we provide a comprehensive resource of precision …

Motivation Alternative RNA splicing plays a crucial role in defining protein function.
However, despite its relevance, there is a lack of tools that characterize effects of splicing on …

Discrete, logic-based models are increasingly used to describe biological mechanisms.
Initially introduced to study gene regulation, these models evolved to cover various …

WikiPathways is a database of 2979 biological pathways across 31 species created using
the drawing software PathVisio. Many of these pathways are not directly usable for network …

Treatment with combinations of drugs carries great promise for personalized therapy for a
variety of diseases. We have previously shown that synergistic combinations of cancer …