Bacterial iron detoxification at the molecular level
JM Bradley, DA Svistunenko, MT Wilson… - Journal of Biological …, 2020 - ASBMB
Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …
Polyphosphate kinase 2 (PPK2) enzymes: structure, function, and roles in bacterial physiology and virulence
Inorganic polyphosphate (polyP) has been implicated in an astonishing array of biological
functions, ranging from phosphorus storage to molecular chaperone activity to bacterial …
functions, ranging from phosphorus storage to molecular chaperone activity to bacterial …
A widespread bacterial protein compartment sequesters and stores elemental sulfur
Subcellular compartments often serve to store nutrients or sequester labile or toxic
compounds. As bacteria mostly do not possess membrane-bound organelles, they often …
compounds. As bacteria mostly do not possess membrane-bound organelles, they often …
Polyphosphate drives bacterial heterochromatin formation
Heterochromatin is most often associated with eukaryotic organisms. Yet, bacteria also
contain areas with densely protein-occupied chromatin that appear to silence gene …
contain areas with densely protein-occupied chromatin that appear to silence gene …
High-resolution temporal profiling of E. coli transcriptional response
Understanding how cells dynamically adapt to their environment is a primary focus of
biology research. Temporal information about cellular behavior is often limited by both small …
biology research. Temporal information about cellular behavior is often limited by both small …
The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling
Ovarian cancer is characterized by dysbiosis, referred to as oncobiosis in neoplastic
diseases. In ovarian cancer, oncobiosis was identified in numerous compartments, including …
diseases. In ovarian cancer, oncobiosis was identified in numerous compartments, including …
The phosphate language of fungi
K Bhalla, X Qu, M Kretschmer, JW Kronstad - Trends in microbiology, 2022 - cell.com
Phosphate is an essential macronutrient for fungal proliferation as well as a key mediator of
antagonistic, beneficial, and pathogenic interactions between fungi and other organisms. In …
antagonistic, beneficial, and pathogenic interactions between fungi and other organisms. In …
Poly (succinimide) nanoparticles as reservoirs for spontaneous and sustained synthesis of poly (aspartic acid) under physiological conditions: potential for vascular …
This paper describes the preparation of poly (succinimide) nanoparticles (PSI NPs) and
investigates their properties and characteristics. Employing direct and inverse precipitation …
investigates their properties and characteristics. Employing direct and inverse precipitation …
a dual-specificity Inhibitor targets polyphosphate kinase 1 and 2 enzymes to attenuate virulence of Pseudomonas aeruginosa
The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of nosocomial
infections, which are becoming increasingly difficult to treat due to antibiotic resistance …
infections, which are becoming increasingly difficult to treat due to antibiotic resistance …
Model systems for studying polyphosphate biology: a focus on microorganisms
A Denoncourt, M Downey - Current Genetics, 2021 - Springer
Polyphosphates (polyP) are polymers of inorganic phosphates joined by high-energy bonds
to form long chains. These chains are present in all forms of life but were once disregarded …
to form long chains. These chains are present in all forms of life but were once disregarded …